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Spironolactone Gammalactone Impurity

SZ CAT No SZ-S017018
CAS No 20802-57-7
Mol.F. C23H32O3
Mol.Wt. 356.5
Inv. Status Custom Synthesis

Chemical Name: (8R,9S,10R,13S,14S,17R)-3-Methoxy-10,13-dimethyl-1,2,3',4',7,8,9,10,11,12,13,14,15,16-tetradecahydro-5'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-5'-one

Smiles: C[C@@]12[C@@](CCC3=O)(O3)CC[C@@]1([H])[C@@](CC=C4[C@@]5(CCC(OC)=C4)C)([H])[C@]5([H])CC2

Inchi: InChI=1S/C32H28N6O7/c1-15-13-36(31-33-21-9-7-19(44-5)11-22(21)34-31)25(17(3)27(15)39)29(41)38-24-10-8-20(45-6)12-23(24)35-32(38)37-14-16(2)28(40)18(4)26(37)30(42)43/h7-14H,1-6H3,(H,33,34)(H,42,43)

RP- HPLC method for the simultaneous estimation of losartan and spironolactone in tablet dosage form
By Chaure, Pravin P.; Sigh, Sonia; Shariff, Arshia; Wagh, Vishalkumar H.; Tandale, Sandeep D.
From Journal of Pharmaceutical Sciences and Research (2019), 11(8), 2866-2871.
Design of experimental approach to analytical robustness study for UHPLC method developed for separation and quantification of spironolactone and its impurities in drug substances
By Veerendra, Y. V. S.; Brahman, Pradeep Kumar; Mankumare, Sharad D.; Ch, Jaya Raju; Satish, J.
From Asian Journal of Chemistry (2020), 32(2), 219-227.
Influence of different chromatographic conditions on the level of detection and quantitation of spironolactone by means of TLC-densitometry
By Dolowy, Malgorzata
From Journal of Analytical Methods in Chemistry (2019), 8792783/1-8792783/8.