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Spironolactone EP Impurity B

SZ CAT No SZ-S017003
CAS No NA
Mol.F. C24H31BrO4S
Mol.Wt. 495.4
Inv. Status In Stock


Chemical Name: S-[(2′R)-4-Bromo-3,5′-dioxo-3′,4′-dihydro-5′H-spiro[androst-4-ene-17,2′-furan]-7α-yl] ethanethioate (as per EP)

Synonym: 4-Bromospironolactone

Smiles: C[C@@]12[C@@]3(OC(CC3)=O)CC[C@@]1([H])[C@]4([H])[C@@](SC(C)=O)([H])CC5=C(Br)C(CC[C@]5(C)[C@@]4([H])CC2)=O

Inchi: InChI=1S/C24H30O4S/c1-14(25)29-19-13-15-12-16(26)4-8-22(15,2)17-5-9-23(3)18(21(17)19)6-10-24(23)11-7-20(27)28-24/h7,11-12,17-19,21H,4-6,8-10,13H2,1-3H3/t17-,18-,19+,21+,22-,23-,24+/m0/s1

RP- HPLC method for the simultaneous estimation of losartan and spironolactone in tablet dosage form
By Chaure, Pravin P.; Sigh, Sonia; Shariff, Arshia; Wagh, Vishalkumar H.; Tandale, Sandeep D.
From Journal of Pharmaceutical Sciences and Research (2019), 11(8), 2866-2871.
 
Design of experimental approach to analytical robustness study for UHPLC method developed for separation and quantification of spironolactone and its impurities in drug substances
By Veerendra, Y. V. S.; Brahman, Pradeep Kumar; Mankumare, Sharad D.; Ch, Jaya Raju; Satish, J.
From Asian Journal of Chemistry (2020), 32(2), 219-227.
 
Influence of different chromatographic conditions on the level of detection and quantitation of spironolactone by means of TLC-densitometry
By Dolowy, Malgorzata
From Journal of Analytical Methods in Chemistry (2019), 8792783/1-8792783/8.