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7-Alpha-Thiomethyl Spironolactone

SZ CAT No SZ-S017011
CAS No 38753-77-4
Mol.F. C23H32O3S 
Mol.Wt. 388.6
Inv. Status Custom Synthesis


Chemical Name: (7R,8R,9S,10R,13S,14S,17S)-10,13-Dimethyl-7-(methylthio)-1,3',4',6,7,8,9,10,11,12,13,14,15,16-tetradecahydro-5'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H)-dione

Smiles: O=C1O[C@@]2(CC1)CC[C@@]3([H])[C@]4([H])[C@H](SC)CC5=CC(CC[C@]5(C)[C@@]4([H])CC[C@]23C)=O

Inchi: InChI=1S/C43H74N2O14S/c1-14-32-43(10,51)36(47)28(6)44(11)23-24(2)21-41(8,50)38(26(4)35(27(5)39(49)57-32)58-33-22-42(9,54-13)37(48)29(7)56-33)59-40-34(46)31(20-25(3)55-40)45(12)60(52,53)30-18-16-15-17-19-30/h15-19,24-29,31-38,40,46-48,50-51H,14,20-23H2,1-13H3/t24-,25?,26+,27-,28-,29+,31+,32-,33+,34-,35+,36-,37?,38?,40+,41-,42-,43-/m1/s1

RP- HPLC method for the simultaneous estimation of losartan and spironolactone in tablet dosage form
By Chaure, Pravin P.; Sigh, Sonia; Shariff, Arshia; Wagh, Vishalkumar H.; Tandale, Sandeep D.
From Journal of Pharmaceutical Sciences and Research (2019), 11(8), 2866-2871.
 
Design of experimental approach to analytical robustness study for UHPLC method developed for separation and quantification of spironolactone and its impurities in drug substances
By Veerendra, Y. V. S.; Brahman, Pradeep Kumar; Mankumare, Sharad D.; Ch, Jaya Raju; Satish, J.
From Asian Journal of Chemistry (2020), 32(2), 219-227.
 
Influence of different chromatographic conditions on the level of detection and quantitation of spironolactone by means of TLC-densitometry
By Dolowy, Malgorzata
From Journal of Analytical Methods in Chemistry (2019), 8792783/1-8792783/8.