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7-Alpha-Thiomethyl Spironolactone

SZ CAT No SZ-S017011
CAS No 38753-77-4
Mol.F. C23H32O3S 
Mol.Wt. 388.6
Inv. Status Custom Synthesis


Chemical Name: (7R,8R,9S,10R,13S,14S,17S)-10,13-Dimethyl-7-(methylthio)-1,3',4',6,7,8,9,10,11,12,13,14,15,16-tetradecahydro-5'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H)-dione

Smiles: O=C1O[C@@]2(CC1)CC[C@@]3([H])[C@]4([H])[C@H](SC)CC5=CC(CC[C@]5(C)[C@@]4([H])CC[C@]23C)=O

Inchi: InChI=1S/C22H32O2/c1-5-24-15-8-10-21(3)18-9-11-22(4)17(6-7-20(22)23)16(18)12-14(2)19(21)13-15/h13,15-18H,2,5-12H2,1,3-4H3/t15?,16-,17-,18-,21+,22-/m0/s1

RP- HPLC method for the simultaneous estimation of losartan and spironolactone in tablet dosage form
By Chaure, Pravin P.; Sigh, Sonia; Shariff, Arshia; Wagh, Vishalkumar H.; Tandale, Sandeep D.
From Journal of Pharmaceutical Sciences and Research (2019), 11(8), 2866-2871.
 
Design of experimental approach to analytical robustness study for UHPLC method developed for separation and quantification of spironolactone and its impurities in drug substances
By Veerendra, Y. V. S.; Brahman, Pradeep Kumar; Mankumare, Sharad D.; Ch, Jaya Raju; Satish, J.
From Asian Journal of Chemistry (2020), 32(2), 219-227.
 
Influence of different chromatographic conditions on the level of detection and quantitation of spironolactone by means of TLC-densitometry
By Dolowy, Malgorzata
From Journal of Analytical Methods in Chemistry (2019), 8792783/1-8792783/8.