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Spironolactone EP Impurity I

SZ CAT No SZ-S017010
Mol.F. C24H36O4S
Mol.Wt. 420.6
Inv. Status In Stock

Chemical Name: S-[17α-(Ethoxymethyl)-17β-hydroxy-3-oxoandrost-4-en-7α-yl] ethanethioate (as per EP); S-[17α-(Ethoxymethyl)-17-hydroxy-3-oxoandrost-4-en-7α-yl]ethanethioate (as per USP)

Synonym: Spironolactone USP Related Compound I

Smiles: C[C@@]12[C@@](COCC)(O)CC[C@@]1([H])[C@]3([H])[C@H](SC(C)=O)CC4=CC(CC[C@]4(C)[C@@]3([H])CC2)=O

Inchi: InChI=1S/C20H26O2/c1-18-8-5-14(21)11-13(18)3-4-15-16(18)6-9-19(2)17(15)7-10-20(19)12-22-20/h3-4,11,15-17H,5-10,12H2,1-2H3/t15-,16+,17+,18+,19+,20-/m1/s1

RP- HPLC method for the simultaneous estimation of losartan and spironolactone in tablet dosage form
By Chaure, Pravin P.; Sigh, Sonia; Shariff, Arshia; Wagh, Vishalkumar H.; Tandale, Sandeep D.
From Journal of Pharmaceutical Sciences and Research (2019), 11(8), 2866-2871.
Design of experimental approach to analytical robustness study for UHPLC method developed for separation and quantification of spironolactone and its impurities in drug substances
By Veerendra, Y. V. S.; Brahman, Pradeep Kumar; Mankumare, Sharad D.; Ch, Jaya Raju; Satish, J.
From Asian Journal of Chemistry (2020), 32(2), 219-227.
Influence of different chromatographic conditions on the level of detection and quantitation of spironolactone by means of TLC-densitometry
By Dolowy, Malgorzata
From Journal of Analytical Methods in Chemistry (2019), 8792783/1-8792783/8.