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Spironolactone

SZ CAT No SZ-S017001
CAS No 52-01-7
Mol.F. C24H32O4S
Mol.Wt. 416.6
Inv. Status In Stock


Chemical Name: S-[(2′R)-3,5′-Dioxo-3′,4′-Dihydro-5′H-spiro[androst-4-ene-17,2′-furan]-7α-yl] ethanethioate (as per EP);(2′R)-7α-(Acetylthio)-3′,4′-dihydro-5′H-spiro[androst-4-ene-17,2′-furan]-3,5′-dione (as per USP)

Smiles: O=C1O[C@@]2(CC1)CC[C@@]3([H])[C@]4([H])[C@H](SC(C)=O)CC5=CC(CC[C@]5(C)[C@@]4([H])CC[C@]23C)=O

Inchi: InChI=1S/C16H13ClF3N5O/c1-9(14-13(20)15(17)23-7-22-14)16(26,5-25-8-21-6-24-25)11-3-2-10(18)4-12(11)19/h2-4,6-9,26H,5H2,1H3/t9-,16+/m0/s1

RP- HPLC method for the simultaneous estimation of losartan and spironolactone in tablet dosage form
By Chaure, Pravin P.; Sigh, Sonia; Shariff, Arshia; Wagh, Vishalkumar H.; Tandale, Sandeep D.
From Journal of Pharmaceutical Sciences and Research (2019), 11(8), 2866-2871.
 
Design of experimental approach to analytical robustness study for UHPLC method developed for separation and quantification of spironolactone and its impurities in drug substances
By Veerendra, Y. V. S.; Brahman, Pradeep Kumar; Mankumare, Sharad D.; Ch, Jaya Raju; Satish, J.
From Asian Journal of Chemistry (2020), 32(2), 219-227.
 
Influence of different chromatographic conditions on the level of detection and quantitation of spironolactone by means of TLC-densitometry
By Dolowy, Malgorzata
From Journal of Analytical Methods in Chemistry (2019), 8792783/1-8792783/8.