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Spironolactone Epimer Mixture

SZ CAT No SZ-S017017
CAS No NA
Mol.F. C24H32O4S
Mol.Wt. 416.6
Inv. Status In Stock


Chemical Name: ((2’R)-7β-(Acetylthio)-3’,4’-dihydro-5’H-spiro[androst-4-ene-17,2’-furan]-3,5’-dione) (as per USP) with ((2’R)-7α-(Acetylthio)-3’,4’-dihydro-5’H-spiro[androst-4-ene-17,2’-furan]-3,5’-dione) (as per USP)

Smiles: O=C1O[C@@]2(CC1)CC[C@@]3([H])[C@]4([H])[C@H](SC(C)=O)CC5=CC(CC[C@]5(C)[C@@]4([H])CC[C@]23C)=O.C[C@@]67[C@]8(CCC(O8)=O)CC[C@@]6([H])[C@]9([H])[C@@H](SC(C)=O)CC%10=CC(CC[C@]%10(C)[C@@]9([H])CC7)=O

Inchi: InChI=1S/C43H69NO12/c1-10-30-18-24(2)17-25(3)19-36(53-8)39-37(54-9)21-27(5)43(51,56-39)40(48)41(49)44-16-12-11-13-31(44)42(50)55-38(28(6)33(46)23-34(30)47)26(4)20-29-14-15-32(45)35(22-29)52-7/h18,20,25,27-33,35-39,45-46,51H,10-17,19,21-23H2,1-9H3/b24-18+,26-20+/t25-,27+,28+,29-,30+,31-,32+,33-,35+,36?,37-,38?,39+,43-/m0/s1

RP- HPLC method for the simultaneous estimation of losartan and spironolactone in tablet dosage form
By Chaure, Pravin P.; Sigh, Sonia; Shariff, Arshia; Wagh, Vishalkumar H.; Tandale, Sandeep D.
From Journal of Pharmaceutical Sciences and Research (2019), 11(8), 2866-2871.
 
Design of experimental approach to analytical robustness study for UHPLC method developed for separation and quantification of spironolactone and its impurities in drug substances
By Veerendra, Y. V. S.; Brahman, Pradeep Kumar; Mankumare, Sharad D.; Ch, Jaya Raju; Satish, J.
From Asian Journal of Chemistry (2020), 32(2), 219-227.
 
Influence of different chromatographic conditions on the level of detection and quantitation of spironolactone by means of TLC-densitometry
By Dolowy, Malgorzata
From Journal of Analytical Methods in Chemistry (2019), 8792783/1-8792783/8.