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Sorafenib EP Impurity E

SZ CAT No SZ-S012017
CAS No 284670-98-0
Mol.F. C27H24N6O5
Mol.Wt. 512.5
Inv. Status In Stock


Chemical Name: 4,4′-[Carbonylbis(azanediyl-4,1-phenyleneoxy)]bis(N-methylpyridine-2-carboxamide) (as per EP) N,N’-Bis{4-[2-(N-methylcarbamoyl)-4-pyridyloxy]phenyl}urea (as per USP)

Synonym: Sorafenib USP Impurity E

Smiles: O=C(NC)C1=CC(OC2=CC=C(NC(NC3=CC=C(OC4=CC=NC(C(NC)=O)=C4)C=C3)=O)C=C2)=CC=N1

Inchi: InChI=1S/C31H26FN3O7/c1-31(32)25(42-28(38)22-15-9-4-10-16-22)23(19-40-27(37)21-13-7-3-8-14-21)41-29(31)35-18-17-24(34-30(35)39)33-26(36)20-11-5-2-6-12-20/h2-18,23,25,29H,19H2,1H3,(H,33,34,36,39)/t23-,25+,29+,31+/m1/s1

Fragmentation pathways and differentiation of positional isomers of sorafenib and structural analogues by ESI-IT-MSn and ESI-Q-TOF-MS/MS coupled with DFT calculations
By Yu, Dandan; Liang, Xianrui
From Journal of Mass Spectrometry (2018), 53(7), 579-589.
 
Box-Behnken design based statistical modelling for optimization of U PLC-MS/MS method for analysis of sorafenib in bulk and tablets
By Wanii, Tanveer A.; Alanazi, Amer M.; Zargar, Seema; Ahmad, Ajaz; Drawish, Ibrahim A.
From Journal of Computational and Theoretical Nanoscience (2015), 12(10), 3598-3604

Determination of sorafenib in human plasma by HPLC
By Liu, Weifeng; Cao, Pengjian; Zhang, Chunfang; Xia, Dongxia; Che, Shujuan; Lou, Dan; Qiu, Xiangjun
From Zhongguo Xiandai Yingyong Yaoxue (2015), 32(2), 182-185