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Sorafenib EP Impurity A

SZ CAT No SZ-S012026
CAS No 284462-37-9
Mol.F. C13H13N3O2
Mol.Wt. 243.3
Inv. Status In Stock

Chemical Name: 4-(4-Aminophenoxy)-N-methylpyridine-2-carboxamide (as per EP); 4-(4-Aminophenoxy)-N-methylpicolinamide (as per USP)

Synonym: Sorafenib USP Impurity A ; Sorafenib Aminophenoxy Impurity

Smiles: O=C(NC)C1=CC(OC2=CC=C(N)C=C2)=CC=N1

Inchi: InChI=1S/C27H23N5O6/c1-28-25(33)23-15-21(11-13-29-23)37-19-7-3-17(4-8-19)31-27(35)32-18-5-9-20(10-6-18)38-22-12-14-30-24(16-22)26(34)36-2/h3-16H,1-2H3,(H,28,33)(H2,31,32,35)

Fragmentation pathways and differentiation of positional isomers of sorafenib and structural analogues by ESI-IT-MSn and ESI-Q-TOF-MS/MS coupled with DFT calculations
By Yu, Dandan; Liang, Xianrui
From Journal of Mass Spectrometry (2018), 53(7), 579-589.
Box-Behnken design based statistical modelling for optimization of U PLC-MS/MS method for analysis of sorafenib in bulk and tablets
By Wanii, Tanveer A.; Alanazi, Amer M.; Zargar, Seema; Ahmad, Ajaz; Drawish, Ibrahim A.
From Journal of Computational and Theoretical Nanoscience (2015), 12(10), 3598-3604

Determination of sorafenib in human plasma by HPLC
By Liu, Weifeng; Cao, Pengjian; Zhang, Chunfang; Xia, Dongxia; Che, Shujuan; Lou, Dan; Qiu, Xiangjun
From Zhongguo Xiandai Yingyong Yaoxue (2015), 32(2), 182-185