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Nifedipine Nitroso Impurity

SZ CAT No SZ-N003015
CAS No NA
Mol.F. C17H17N3O7
Mol.Wt. 375.3
Inv. Status Custom Synthesis


Chemical Name: Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1-nitroso-1,4-dihydropyridine-3,5-dicarboxylate

Smiles: O=C(C1=C(C)N(N=O)C(C)=C(C(OC)=O)C1C2=CC=CC=C2[N+]([O-])=O)OC

Inchi: InChI=1S/C22H23ClF4N8O3/c23-12-6-11(22(25,26)27)7-13(8-12)35(32-38)15-2-1-4-34(21(15)37)16-9-33(5-3-14(16)19(29)36)20-17(24)18(28)30-10-31-20/h6-8,10,14-16H,1-5,9H2,(H2,29,36)(H2,28,30,31)/t14-,15+,16-/m0/s1

Rapid characterization of impurities in the bulk drug of nifedipine by high performance liquid chromatography-quadrupole time of fight mass spectrometry
Peixi Zhu 1, Lixi Ding, Jiajia He, Guogang Zheng
Se Pu. 2012 Oct;30(10):1026-30.
 
Development and validation of rp-hplc method for the estimation of process related impurity from nifedipine
Dr.Manisha. S. Kedar1* , Dr.Manoj. P. Shirbhate2 , Manjusha. S. Sanap3 , Dr.Rani. S. Kankate4 , Prerana. B. Jadhav5 and Bhagyashri. J. Warude
European Journal of Molecular & Clinical Medicine Volume 7, Issue 8, 2020; 5593-5601
 
Validation of an HPLC Method for Nifedipine and its Related Substances in Raw Materials
N. Beaulieu ,N. M. Curran,S. J. Graham,R. W. Sears &E. G. Lovering
Journal of Liquid Chromatography  Volume 14, 1991 - Issue 6 Pages 1173-1183
 
Development and characterization of ethylcellulose based microsphere for sustained release of nifedipine
PatitapabanaParidaaSubash ChandraMishrabSubhashreeSahoocAjitBeheradBibhukalyan PrasadNayak
Journal of Pharmaceutical Analysis Volume 6, Issue 5, October 2016, Pages 341-344