Chemical Name: (1S,3S)-1-[(1S)-1-[[2-(2,6-Dimethylphenoxy)acetyl]amino]-2-phenylethyl]-3-[[(2S)-3-methyl-2-[2-oxotetrahydropyrimidin-1(2H)-yl]butanoyl]amino]-4phenylbutyl(2S)-3-methyl-2-[2-oxotetrahydropyrimidin1(2H)-yl]butanoate (as per EP); (S)-{(2S,3S,5S)-2-[2-(2,6-Dimethylphenoxy)acetamido]-5-[(S)-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanamido]-1,6-diphenylhexan-3-yl} 3-methyl-2-[2-oxotetrahydropyrimidin-1(2H)-yl]butanoate (as per USP)
Synonym: Lopinavir O-Acyl Impurity (USP)
Smiles: O=C1NCCCN1[C@@H](C(C)C)C(N[C@@H](CC2=CC=CC=C2)C[C@H](OC([C@H](N3CCCNC3=O)C(C)C)=O)[C@H](CC4=CC=CC=C4)NC(COC5=C(C)C=CC=C5C)=O)=O
Inchi: InChI=1S/C37H48N4O5/c1-25(2)34(41-20-12-19-38-37(41)45)36(44)39-30(21-28-15-7-5-8-16-28)23-32(42)31(22-29-17-9-6-10-18-29)40-33(43)24-46-35-26(3)13-11-14-27(35)4/h5-11,13-18,25,30-32,34,42H,12,19-24H2,1-4H3,(H,38,45)(H,39,44)(H,40,43)/t30-,31-,32+,34-/m0/s1
Stability indicative and cost effective creation and validation of analytical method of Lopinavir and Rilpivirine by high performance liquid chromatography
By Srinivas, L.; Jain, Neelu
From International Journal of Research in Pharmaceutical Sciences (Madurai, India) (2021), 12(1), 786-792
Analytical methods development & validation for simultaneous estimation of lopinavir & ritonavir in pharmaceutical formulation by simultaneous equation method using UV spectrophotometry
By Jadhav, Sarika R.; Alhat, Hemant P.; Joshi, Suhas
From International Research Journal of Pharmacy (2018), 9(8), 57-62
Development and validation of forced degradation studies of lopinavir using RP-HPLC and characterization of degradants by LC-MS/MS
By Bhavyasri, Khagga; Balaram, V. Murali; Nageswarao, R.; Rambabu, D.; Ajitha, M.
From International Journal of Chemical Sciences (2015), 13(1), 551-562
