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Lopinavir EP Impurity I

SZ CAT No SZ-L008010
CAS No NA
Mol.F. C37H48N4O5 
Mol.Wt. 628.8
Inv. Status In Stock


Chemical Name: (2S)-N-[(1S,2S,4S)-1-Benzyl-4-[[2-(2,6-dimethylphenoxy)acetyl]amino]-2-hydroxy-5-phenylpentyl]-3-methyl-2-[2oxotetrahydropyrimidin-1(2H)-yl]butanamide (as per EP); (S)-N-{(2S,3S,5S)-5-[2-(2,6-Dimethylphenoxy)acetamido]-3-hydroxy-1,6-diphenylhexan-2-yl}-3-methyl-2-[2-oxotetrahydropyrimidin-1(2H)-yl]butanamide (as per USP)

Synonym: Isolopinavir (USP)

Smiles: CC(C)[C@@H](N1CCCNC1=O)C(N[C@H](CC2=CC=CC=C2)[C@H](O)C[C@H](NC(COC3=C(C)C=CC=C3C)=O)CC4=CC=CC=C4)=O

Inchi: InChI=1S/C29H32N2O4/c1-20-10-9-11-21(2)28(20)34-19-27(32)31-25(17-23-14-7-4-8-15-23)26-18-24(30-29(33)35-26)16-22-12-5-3-6-13-22/h3-15,24-26H,16-19H2,1-2H3,(H,30,33)(H,31,32)/t24-,25-,26-/m0/s1

Stability indicative and cost effective creation and validation of analytical method of Lopinavir and Rilpivirine by high performance liquid chromatography
By Srinivas, L.; Jain, Neelu
From International Journal of Research in Pharmaceutical Sciences (Madurai, India) (2021), 12(1), 786-792
 
Analytical methods development & validation for simultaneous estimation of lopinavir & ritonavir in pharmaceutical formulation by simultaneous equation method using UV spectrophotometry
By Jadhav, Sarika R.; Alhat, Hemant P.; Joshi, Suhas
From International Research Journal of Pharmacy (2018), 9(8), 57-62
 
Development and validation of forced degradation studies of lopinavir using RP-​HPLC and characterization of degradants by LC-​MS​/MS
By Bhavyasri, Khagga; Balaram, V. Murali; Nageswarao, R.; Rambabu, D.; Ajitha, M.
From International Journal of Chemical Sciences (2015), 13(1), 551-562