Chemical Name: (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-Dihydroxy-3-[(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-propyl-3,4,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-octadecahydro-7H-15,19-epoxypyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(23H)-tetrone (as per EP);(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)- 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-{(E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylvinyl}-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-8-propyl-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone (as per USP)
Synonym: Tacrolimus 8-Propyl Analog (USP)
Smiles: O[C@H]1[C@H](OC)C[C@H](/C=C(C)/[C@@H](OC([C@@H]2N(C(C([C@@]3(O)[C@H](C)C[C@H](OC)[C@]4([H])O3)=O)=O)CCCC2)=O)[C@H](C)[C@@H](O)CC([C@H](CCC)/C=C(C[C@H](C)C[C@@H]4OC)\C)=O)CC1
Inchi: InChI=1S/C17H17Cl2N.ClH/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11;/h2-6,8,10,12,17,20H,7,9H2,1H3;1H/t12-,17-;/m1./s1
Development and validation of a stability indicating HPLC assay method for tacrolimus in semi-solid dosage form & bulk drug
By Gejage, Santosh; Amin, Purnima
From Indo American Journal of Pharmaceutical Research (2018), 8(5), 1097-1106