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Spironolactone Impurity 2

SZ CAT No SZ-S017014
CAS No 4138-96-9
Mol.F. C22H30O4 
Mol.Wt. 358.5
Inv. Status Custom Synthesis
Rel. CAS No 5285-14-3 (Na salt) ; 2181-04-6 (K salt)

Chemical Name: 3-((8R,9S,10R,13S,14S,17R)-17-Hydroxy-10,13-dimethyl-3-oxo-2,3,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)propanoic acid

Smiles: C[C@@]12[C@@]3([H])CC[C@@]([C@](O)(CCC(O)=O)CC4)(C)[C@]4([H])[C@]3([H])C=CC1=CC(CC2)=O

Inchi: InChI=1S/C23H32O4S/c1-21-8-4-15(24)12-14(21)13-18(28(3)26)20-16(21)5-9-22(2)17(20)6-10-23(22)11-7-19(25)27-23/h12,16-18,20H,4-11,13H2,1-3H3/t16-,17-,18+,20+,21-,22-,23+,28-/m0/s1

RP- HPLC method for the simultaneous estimation of losartan and spironolactone in tablet dosage form
By Chaure, Pravin P.; Sigh, Sonia; Shariff, Arshia; Wagh, Vishalkumar H.; Tandale, Sandeep D.
From Journal of Pharmaceutical Sciences and Research (2019), 11(8), 2866-2871.
Design of experimental approach to analytical robustness study for UHPLC method developed for separation and quantification of spironolactone and its impurities in drug substances
By Veerendra, Y. V. S.; Brahman, Pradeep Kumar; Mankumare, Sharad D.; Ch, Jaya Raju; Satish, J.
From Asian Journal of Chemistry (2020), 32(2), 219-227.
Influence of different chromatographic conditions on the level of detection and quantitation of spironolactone by means of TLC-densitometry
By Dolowy, Malgorzata
From Journal of Analytical Methods in Chemistry (2019), 8792783/1-8792783/8.