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Raltegravir EP Impurity F

SZ CAT No SZ-R009007
CAS No NA
Mol.F. C22H27FN6O6
Mol.Wt. 490.5
Inv. Status Under Synthesis


Chemical Name: Ethyl (1E)-N-[[2-[4-[[(4-fluorophenyl)methyl]carbamoyl]-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl]propan-2-yl]oxamoyl]ethanehydrazonate (as per EP); Ethyl (E)-N-{2-[(2-{4-[(4-fluorobenzyl)carbamoyl]-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl}propan-2-yl)amino]-2-oxoacetyl}acetohydrazonate (as per USP)

Synonym: Raltegravir E-ethoxyacethydrazone analog

LCMS using a hybrid quadrupole time of flight mass spectrometer for impurity identification during process chemical development of a novel integrase inhibitor
T.J. Novaka,∗, N. Grinberg b, B. Hartmana, S. Marcinkoa, L. DiMichelea, B. Mao
Journal of Pharmaceutical and Biomedical Analysis 51 (2010) 78–83
 
Rp-hplc method development and validation for simultanious estimation and forced degradation studies of lamivudine and raltegravir in solid dosage form
Juluri krishna dutta tejaswi1*, r. govinda rajan
Int J App Pharm, Vol 10, Issue 6, 2018, 242-248
 
Quantitative Reverse-phase High-performance Liquid Chromatographic Method for the Quantification of Raltegravir Potassium in Bulk and Dosage Forms
Sonam Patel, Krishnaveni Nagappan*, Gouru Santhosh Reddy, Gullapalli Kowmudi
J Young Pharm, 2019;11(3):274-278