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Posaconazole 1-oxido impurity + Posaconazole 4-oxido impurity

SZ CAT No SZ-P022130
Mol.F. C37H42F2N8O5 : C2HF3O2
Mol.Wt. 716.8 : 114.0
Inv. Status Out of Stock

Chemical Name: 1-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)-4-(4-(1-((2S,3S)-2-hydroxypentan-3-yl)-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl)phenyl)piperazine 1-oxide 4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)-1-(4-(1-((2S,3S)-2-hydroxypentan-3-yl)-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl)phenyl)piperazine 1-oxide 2,2,2-trifluoroacetate

Smiles: FC1=C(C=CC(F)=C1)[C@]2(C[C@H](COC3=CC=C(N(CC4)CC[N]4(C5=CC=C(N(C=NN6[C@@H](CC)[C@@H](O)C)C6=O)C=C5)=O)C=C3)CO2)CN7C=NC=N7.FC8=C(C=CC(F)=C8)[C@]9(C[C@H](COC%10=CC=C([N]%11(CCN(C%12=CC=C(N(C=NN%13[C@@H](CC)[C@@H](O)C)C%13=O)C=C%12)CC%11)=O)C=C%10)CO9)CN%14C=NC=N%14.O=C(O)C(F)(F)F

Inchi: InChI=1S/C25H29ClO8/c1-14(28)32-25-23(30)22(29)21(12-27)34-24(25)16-4-7-20(26)17(11-16)10-15-2-5-18(6-3-15)33-19-8-9-31-13-19/h2-7,11,19,21-25,27,29-30H,8-10,12-13H2,1H3/t19-,21+,22+,23-,24-,25+/m0/s1

Influence of cyclodextrin on posaconazole stability, release and activity: Improve the utility of the drug
By Santana, Ana Cristina Sousa Gramoza Vilarinho; Nadvorny, Daniela; da Rocha Passos, Taisa Daiany; de La Roca Soares, Monica Felts; Soares-Sobrinho, Jose Lamartine
From Journal of Drug Delivery Science and Technology (2019), 53, 101153
Stability-​indicating HPLC method development and structural elucidation of novel degradation products in posaconazole injection by LC-​TOF​/MS, LC-​MS​/MS and NMR
By Yang, Yidi; Zhu, Xi; Zhang, Fei; Li, Wei; Wu, Ying; Ding, Li
From Journal of Pharmaceutical and Biomedical Analysis (2016), 125, 165-177
Stability indicating HPLC method for the quantification of posaconazole and its related substances
By Govind, Sampath Kumar Reddy; Nagaraju, Ch. V. S.; Rajan, S. T.; Eshwaraiah, S.; Kishore, M.; Rakesh, M.; Chakravarthy, I. E.
From Pharma Chemica (2014), 6(1), 486-494, 9 pp..