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Piperacillin EP Impurity K

SZ CAT No SZ-P048028
Mol.F. C23H27N5O7S 
Mol.Wt. 517.6
Inv. Status Under Synthesis

Chemical Name: (2Ξ)-2-[[(E)-[2-[(R)-[(4-ethyl-2,3-dioxopiperazine-1-carboxamido)phenylmethyl]-5-oxo-1,3-oxazol-4(5H)-ylidene]methyl]amino]-3-methyl-3-sulfanylbutanoic acid (penicillenic acid) (as per EP)

Smiles: O=C(N1C(C(N(CC)CC1)=O)=O)N[C@@H](C2=N/C(C(O2)=O)=C/NC(C(C)(S)C)C(O)=O)C3=CC=CC=C3

Quantification of cefepime, meropenem, piperacillin, and tazobactam in human plasma using a sensitive and robust liquid chromatography-​tandem mass spectrometry method, part 2: stability evaluation
By D'cunha, Ronilda; Bach, Thanh; Young, Beth Ann; Li, Peizhi; Nalbant, Demet; Zhang, Jun; Winokur, Patricia; An, Guohua
From Antimicrobial Agents and Chemotherapy (2018), 62(9), e00861-18/1-e00861-18/9
Stability indicating RP-​HPLC method for the determination of Piperacillin and Tazobactam and their related substances in bulk and pharmaceutical formulation
By Navle, Khyathi; Prasanna, B. Lakshmi; Dometti, Hema Sree; Moodu, Shankar
From World Journal of Pharmacy and Pharmaceutical Sciences (2017), 6(8), 1760-1774

Therapeutic drug monitoring of beta-​lactam antibiotics - Influence of sample stability on the analysis of piperacillin, meropenem, ceftazidime and flucloxacillin by HPLC-​UV
By Pinder, Nadine; Brenner, Thorsten; Swoboda, Stefanie; Weigand, Markus A.; Hoppe-Tichy, Torsten
From Journal of Pharmaceutical and Biomedical Analysis (2017), 143, 86-93