Chemical Name: (4-(2-(2,2'-Diamino-5-(4-((1-carboxy-4-(2-carboxyethoxy)-4-oxobutyl)carbamoyl)phenethyl)-6-hydroxy-4,4'-dioxo-4,4',5,6,7,7'-hexahydro-3H,3'H-[5,6'-bipyrrolo[2,3-d]pyrimidin]-5'-yl)ethyl)benzoyl)glutamic acid
Smiles: O=C1C2=C(NC(C3(CCC4=CC=C(C(NC(CCC(OCCC(O)=O)=O)C(O)=O)=O)C=C4)C(O)NC5=C3C(NC(N)=N5)=O)=C2CCC6=CC=C(C(NC(CCC(O)=O)C(O)=O)=O)C=C6)N=C(N)N1
Inchi: InChI=1S/C54H56N2O21/c1-19-43(60)25(55)11-33(74-19)76-29-15-53(70,13-23-37(29)51(68)41-39(47(23)64)45(62)21-7-5-9-27(72-3)35(21)49(41)66)31(58)17-56-26-12-34(75-20(2)44(26)61)77-30-16-54(71,32(59)18-57)14-24-38(30)52(69)42-40(48(24)65)46(63)22-8-6-10-28(73-4)36(22)50(42)67/h5-10,19-20,25-26,29-30,33-34,43-44,56-57,60-61,64-65,68-71H,11-18,55H2,1-4H3/t19-,20-,25-,26-,29-,30-,33-,34-,43+,44+,53-,54-/m0/s1
A stability-indicating LC-MS/MS method optimization for Pemetrexed through design of experiments: Identification and characterization of major oxidative degradation product
By Narenderan, S. T.; Ramesh, J.; Babu, B.; Meyyanathan, S. N.
From Journal of Pharmaceutical and Biomedical Analysis (2020), 183, 113150
A new validated stability-indicating gradient RP-HPLC method for the determination of pemetrexed disodium and its process related substances
By Hemchand, S.; Babu, R. Ravi Chandra; Annapurna, Mukthinuthalapati Mathrusri
From Journal of Drug Delivery and Therapeutics (2019), 9(3Suppl.), 588-610
Content determination of related impurity-L-isomer in Pemetrexed Disodium for injection by HPLC
By Li, Jinhua; Yang, Mei
From Heilongjiang Yiyao (2014), 27(3), 498-500