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Loteprednol Impurity 9

SZ CAT No SZ-L034017
CAS No NA
Mol.F. C24H29ClO7
Mol.Wt. 464.9
Inv. Status Custom Synthesis


Chemical Name: Chloromethyl (10S,11S,13S,17R)-17-((ethoxycarbonyl)oxy)-11-hydroxy-10,13-dimethyl-3-oxo-6,7,10,11,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthrene-17-carboxylate

Smiles: C[C@@]12C(CCC3=C2[C@@H](O)C[C@@]4(C)C3CC[C@]4(OC(OCC)=O)C(OCCl)=O)=CC(C=C1)=O

Inchi: InChI=1/C23H26N2O2.C4H6O4/c26-23(27-21-16-24-13-10-18(21)11-14-24)25-15-12-17-6-4-5-9-20(17)22(25)19-7-2-1-3-8-19;5-3(6)1-2-4(7)8/h1-9,18,21-22H,10-16H2;1-2H2,(H,5,6)(H,7,8)

Potential Use of Cyclodextrin Complexes for Enhanced Stability, Anti-​inflammatory Efficacy, and Ocular Bioavailability of Loteprednol Etabonate
By Soliman, Osama Abd El-Aazeem; Mohamed, Elham Abdel Monem; El-Dahan, Marwa Salah; Khatera, Nabil Abdullah Ali
From AAPS PharmSciTech (2017), 18(4), 1228-1241
 
Determination of edetate disodium dihydrate in loteprednol and tobramycin ophthalmic suspension by RP-​HPLC
By Xue, Qi; Yang, Longhua
From Zhongguo Yaoye (2012), 21(1), 24-25

An HPLC method to evaluate purity of a steroidal drug, loteprednol etabonate
By Yasueda, Shin-ichi; Higashiyama, Masayo; Shirasaki, Yoshihisa; Inada, Katsuhiro; Ohtori, Akira
From Journal of Pharmaceutical and Biomedical Analysis (2004), 36(2), 309-316