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Losartan EP Impurity I

SZ CAT No SZ-L028010
CAS No 1006062-28-7
Mol.F. C41H37ClN6O
Mol.Wt. 665.2
Inv. Status Custom Synthesis


Chemical Name: 5-[4'-[[2-Butyl-4-chloro-5-[(triphenyl methoxy)methyl]-1H-imidazol-1-yl]methyl] [1,1'-biphenyl]-2-yl]-2H-tetrazole

Synonym: O-Trityl Losartan ; Losartan Trityl Ether

Development and validation of a stability-indicating HPLC method for the simultaneous determination of Losartan potassium, hydrochlorothiazide, and their degradation products
Deanne L. Hertzog a,*, Jennifer Finnegan McCafferty b , Xueguang Fang b , R. Jeffrey Tyrrell c , Robert A. Reed
Journal of Pharmaceutical and Biomedical Analysis 30 (2002) 747–760
 
An Efficient, Commercially Viable, and Safe Process for Preparation of Losartan Potassium, an Angiotensin II Receptor Antagonist
Suri Babu Madasu,†,‡ N. A. Vekariya,*,† Ch Koteswaramma,† Aminul Islam,† Paul Douglas Sanasi,‡ and Raghu Babu Korupolu
Org. Process Res. Dev. 2012, 16, 12, 2025–2030