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Lopinavir EP Impurity S

SZ CAT No SZ-L008020
CAS No 943250-65-5
Mol.F. C47H58N4O7 
Mol.Wt. 791.0
Inv. Status In Stock


Chemical Name: (1S,3S)-1-[(1S)-1-[[2-(2,6-Dimethylphenoxy)acetyl]amino]-2-phenylethyl]-3-[[(2S)-3-methyl-2-[2-oxotetrahydropyrimidin-1(2H)-yl]butanoyl]amino]-4phenylbutyl2-(2,6-dimethylphenoxy)acetate (as per EP); (2S,3S,5S)-2-[2-(2,6-Dimethylphenoxy)acetamido]-5-{(S)-3-methyl-2-[2-oxotetrahydropyrimidin-1(2H)-yl]butanamido}-1,6-diphenylhexan-3-yl 2-(2,6-dimethylphenoxy)acetate (as per USP)

Synonym: Lopinavir O-Phenoxyacetyl (USP)

Smiles: O=C(COC(C(C)=CC=C1)=C1C)O[C@@H](C[C@@H](NC([C@@H](N(CCCN2)C2=O)C(C)C)=O)CC3=CC=CC=C3)[C@](NC(COC(C(C)=CC=C4)=C4C)=O)([H])CC5=CC=CC=C5

Inchi: InChI=1S/C47H58N4O7/c1-31(2)43(51-25-15-24-50(47(51)56)42(54)30-58-45-34(5)18-14-19-35(45)6)46(55)48-38(26-36-20-9-7-10-21-36)28-40(52)39(27-37-22-11-8-12-23-37)49-41(53)29-57-44-32(3)16-13-17-33(44)4/h7-14,16-23,31,38-40,43,52H,15,24-30H2,1-6H3,(H,48,55)(H,49,53)/t38-,39-,40-,43-/m0/s1

Stability indicative and cost effective creation and validation of analytical method of Lopinavir and Rilpivirine by high performance liquid chromatography
By Srinivas, L.; Jain, Neelu
From International Journal of Research in Pharmaceutical Sciences (Madurai, India) (2021), 12(1), 786-792
 
Analytical methods development & validation for simultaneous estimation of lopinavir & ritonavir in pharmaceutical formulation by simultaneous equation method using UV spectrophotometry
By Jadhav, Sarika R.; Alhat, Hemant P.; Joshi, Suhas
From International Research Journal of Pharmacy (2018), 9(8), 57-62
 
Development and validation of forced degradation studies of lopinavir using RP-​HPLC and characterization of degradants by LC-​MS​/MS
By Bhavyasri, Khagga; Balaram, V. Murali; Nageswarao, R.; Rambabu, D.; Ajitha, M.
From International Journal of Chemical Sciences (2015), 13(1), 551-562