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Lopinavir EP Impurity R 

SZ CAT No SZ-L008019
CAS No 943250-66-6
Mol.F. C47H58N4O7
Mol.Wt. 791.0
Inv. Status In Stock


Chemical Name: (2S)-N-[(1S,3S,4S)-1-Benzyl-4-[[2-(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenylpentyl]-2-[3-[2-(2,6dimethylphenoxy)acetyl]-2-oxotetrahydropyrimidin1(2H)-yl]-3-methylbutanamide (as per EP); (S)-N-{(2S,4S,5S)-5-[2-(2,6-Dimethylphenoxy)acetamido]-4-hydroxy-1,6-diphenylhexan-2-yl}-2-{3-[2-(2,6-dimethylphenoxy)acetyl]-2-oxotetrahydropyrimidin-1(2H)-yl}-3-methylbutanamide (as per USP)

Synonym: Lopinavir N-Acyl Impurity (USP)

Smiles: CC(C)[C@H](N1CCCN(C(COC2=C(C)C=CC=C2C)=O)C1=O)C(N[C@@H](CC3=CC=CC=C3)C[C@H](O)[C@@H](NC(COC4=C(C)C=CC=C4C)=O)CC5=CC=CC=C5)=O

Inchi: InChI=1S/C38H44N2O5/c1-26-13-11-14-27(2)37(26)44-24-35(42)39-32(21-30-17-7-5-8-18-30)23-34(41)33(22-31-19-9-6-10-20-31)40-36(43)25-45-38-28(3)15-12-16-29(38)4/h5-20,32-34,41H,21-25H2,1-4H3,(H,39,42)(H,40,43)/t32-,33-,34-/m0/s1

Stability indicative and cost effective creation and validation of analytical method of Lopinavir and Rilpivirine by high performance liquid chromatography
By Srinivas, L.; Jain, Neelu
From International Journal of Research in Pharmaceutical Sciences (Madurai, India) (2021), 12(1), 786-792
 
Analytical methods development & validation for simultaneous estimation of lopinavir & ritonavir in pharmaceutical formulation by simultaneous equation method using UV spectrophotometry
By Jadhav, Sarika R.; Alhat, Hemant P.; Joshi, Suhas
From International Research Journal of Pharmacy (2018), 9(8), 57-62
 
Development and validation of forced degradation studies of lopinavir using RP-​HPLC and characterization of degradants by LC-​MS​/MS
By Bhavyasri, Khagga; Balaram, V. Murali; Nageswarao, R.; Rambabu, D.; Ajitha, M.
From International Journal of Chemical Sciences (2015), 13(1), 551-562