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Fosaprepitant Phosphoryl Impurity

SZ CAT No SZ-F017028
CAS No NA
Mol.F. C23H23F7N4O9P2
Mol.Wt. 694.4
Inv. Status Custom Synthesis


Chemical Name: (3-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-2,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic phosphoric anhydride

Smiles: O=P(O)(OP(N1NC(CN2[C@@H](C3=CC=C(F)C=C3)[C@@H](O[C@@H](C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)C)OCC2)=NC1=O)(O)=O)O

Inchi: InChI=1S/C15H22N4O3/c1-4-8-18-10-16-13-12(18)14(21)19(15(22)17(13)3)9-6-5-7-11(2)20/h10H,4-9H2,1-3H3

GC-​FID technique for the quantitative evaluation of multiple residual organic solvent impurities in fosaprepitant dimeglumine drug
By Reddy, H. Ramakrishna; Pratap, S. R.; Chandrasekhar, N.; Shamshuddin, S. Z. M.
From Asian Journal of Chemistry (2021), 33(7), 1645-1650
 
Quantification and method validation of dicyclohexylurea content in fosaprepitant dimeglumine drug substance by reverse phase HPLC
By Kishore, M. V.; Sivarao, T.; Srinivas, K. Rama; Satyendranath, Ch. V.; Kumar, Vundavilli Jagadeesh; Kumar, K. S. R. Pavan; Sreenivas, N.
From International Journal of Pharmaceutical Sciences and Research (2020), 11(10), 5010-5016

Quality by design approach for development and validation of stability indicating RP-​HPLC method for fosaprepitant dimeglumine
By Shaikh, Jalil K.; Farooqui, Mazahar; Syed, Ummul Khair Asema
From Asian Journal of Chemistry (2020), 32(9), 2158-2164