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Fosaprepitant Impurity 9

SZ CAT No SZ-F017014
CAS No NA
Mol.F. C23H21F7N4O5P : C7H18NO5
Mol.Wt. 597.4 : 196.2
Inv. Status Custom Synthesis


Chemical Name: (2S,3R,4R,5R)-2,3,4,5,6-Pentahydroxy-N-methylhexan-1-aminium (3-((1S)-(1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)(4-fluorophenyl)(morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphinate

Smiles: O[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)C[NH2+]C.O=P(N1N=C([C@](C2=CC=C(F)C=C2)(OC(C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)C)N4CCOCC4)NC1=O)[O-]

Inchi: InChI=1S/C23H23F6N4O6P.C7H17NO5/c1-13(15-9-16(22(24,25)26)11-17(10-15)23(27,28)29)39-20-19(14-5-3-2-4-6-14)32(7-8-38-20)12-18-30-21(34)33(31-18)40(35,36)37;1-8-2-4(10)6(12)7(13)5(11)3-9/h2-6,9-11,13,19-20H,7-8,12H2,1H3,(H,30,31,34)(H2,35,36,37);4-13H,2-3H2,1H3/t13-,19+,20-;4-,5+,6+,7+/m10/s1

GC-​FID technique for the quantitative evaluation of multiple residual organic solvent impurities in fosaprepitant dimeglumine drug
By Reddy, H. Ramakrishna; Pratap, S. R.; Chandrasekhar, N.; Shamshuddin, S. Z. M.
From Asian Journal of Chemistry (2021), 33(7), 1645-1650
 
Quantification and method validation of dicyclohexylurea content in fosaprepitant dimeglumine drug substance by reverse phase HPLC
By Kishore, M. V.; Sivarao, T.; Srinivas, K. Rama; Satyendranath, Ch. V.; Kumar, Vundavilli Jagadeesh; Kumar, K. S. R. Pavan; Sreenivas, N.
From International Journal of Pharmaceutical Sciences and Research (2020), 11(10), 5010-5016

Quality by design approach for development and validation of stability indicating RP-​HPLC method for fosaprepitant dimeglumine
By Shaikh, Jalil K.; Farooqui, Mazahar; Syed, Ummul Khair Asema
From Asian Journal of Chemistry (2020), 32(9), 2158-2164