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Fosaprepitant Impurity 8

SZ CAT No SZ-F017027
CAS No NA
Mol.F. C23H21F7N4O3
Mol.Wt. 534.4
Inv. Status Custom Synthesis


Chemical Name: 5-(((2R,3S)-3-((S)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-2-(4-fluorophenyl)morpholino)methyl)-1,2-dihydro-3H-1,2,4-triazol-3-one

Smiles: O=C1NNC(CN2[C@@H](O[C@H](C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)C)[C@@H](C4=CC=C(F)C=C4)OCC2)=N1

Inchi: InChI=1S/C6H8N4O3/c1-9-4(7)3(8-13)5(11)10(2)6(9)12/h7H2,1-2H3

GC-​FID technique for the quantitative evaluation of multiple residual organic solvent impurities in fosaprepitant dimeglumine drug
By Reddy, H. Ramakrishna; Pratap, S. R.; Chandrasekhar, N.; Shamshuddin, S. Z. M.
From Asian Journal of Chemistry (2021), 33(7), 1645-1650
 
Quantification and method validation of dicyclohexylurea content in fosaprepitant dimeglumine drug substance by reverse phase HPLC
By Kishore, M. V.; Sivarao, T.; Srinivas, K. Rama; Satyendranath, Ch. V.; Kumar, Vundavilli Jagadeesh; Kumar, K. S. R. Pavan; Sreenivas, N.
From International Journal of Pharmaceutical Sciences and Research (2020), 11(10), 5010-5016

Quality by design approach for development and validation of stability indicating RP-​HPLC method for fosaprepitant dimeglumine
By Shaikh, Jalil K.; Farooqui, Mazahar; Syed, Ummul Khair Asema
From Asian Journal of Chemistry (2020), 32(9), 2158-2164