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Fosaprepitant Impurity 1

SZ CAT No SZ-F017019
CAS No 1185503-00-7
Mol.F. C23H22F7N4O6P
Mol.Wt. 614.4
Inv. Status In Stock
Rel. CAS No 1523569-88-1 (dimeglumine salt) ; 1185503-00-7 (Free base)


Chemical Name: (3-(((2S,3R)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic acid

Smiles: O=C1NC(CN2[C@H](C3=CC=C(F)C=C3)[C@H](O[C@@H](C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)C)OCC2)=NN1P(O)(O)=O

Inchi: InChI=1S/C42H58O9/c1-38-14-11-23(43)17-21(38)5-7-25-27-9-10-29(40(27,3)19-30(45)32(25)38)34(47)35(48)36(49)37(50)42(51)16-13-28-26-8-6-22-18-24(44)12-15-39(22,2)33(26)31(46)20-41(28,42)4/h17-18,25-33,35-36,45-46,48-49,51H,5-16,19-20H2,1-4H3/t25?,26?,27?,28?,29-,30+,31+,32?,33?,35?,36?,38+,39+,40+,41+,42+/m1/s1

GC-​FID technique for the quantitative evaluation of multiple residual organic solvent impurities in fosaprepitant dimeglumine drug
By Reddy, H. Ramakrishna; Pratap, S. R.; Chandrasekhar, N.; Shamshuddin, S. Z. M.
From Asian Journal of Chemistry (2021), 33(7), 1645-1650
 
Quantification and method validation of dicyclohexylurea content in fosaprepitant dimeglumine drug substance by reverse phase HPLC
By Kishore, M. V.; Sivarao, T.; Srinivas, K. Rama; Satyendranath, Ch. V.; Kumar, Vundavilli Jagadeesh; Kumar, K. S. R. Pavan; Sreenivas, N.
From International Journal of Pharmaceutical Sciences and Research (2020), 11(10), 5010-5016

Quality by design approach for development and validation of stability indicating RP-​HPLC method for fosaprepitant dimeglumine
By Shaikh, Jalil K.; Farooqui, Mazahar; Syed, Ummul Khair Asema
From Asian Journal of Chemistry (2020), 32(9), 2158-2164