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Fosaprepitant Dimeglumine Impurity C

SZ CAT No SZ-F017004
CAS No 170729-80-3
Mol.F. C23H21F7N4O3
Mol.Wt. 534.4
Inv. Status In Stock
Rel. CAS No 2563866-47-5 (HCl salt)


Chemical Name: 5-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

Synonym: Aprepitant

Smiles: FC1=CC=C([C@@H]2N(CC3=NNC(N3)=O)CCO[C@@H]2O[C@@H](C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)C)C=C1

Inchi: InChI=1S/C24H25F7N4O4/c1-13(15-9-16(23(26,27)28)11-17(10-15)24(29,30)31)39-21-20(14-3-5-18(25)6-4-14)35(7-8-38-21)12-19(32)33-34-22(36)37-2/h3-6,9-11,13,20-21H,7-8,12H2,1-2H3,(H2,32,33)(H,34,36)/t13-,20+,21-/m1/s1

GC-​FID technique for the quantitative evaluation of multiple residual organic solvent impurities in fosaprepitant dimeglumine drug
By Reddy, H. Ramakrishna; Pratap, S. R.; Chandrasekhar, N.; Shamshuddin, S. Z. M.
From Asian Journal of Chemistry (2021), 33(7), 1645-1650
 
Quantification and method validation of dicyclohexylurea content in fosaprepitant dimeglumine drug substance by reverse phase HPLC
By Kishore, M. V.; Sivarao, T.; Srinivas, K. Rama; Satyendranath, Ch. V.; Kumar, Vundavilli Jagadeesh; Kumar, K. S. R. Pavan; Sreenivas, N.
From International Journal of Pharmaceutical Sciences and Research (2020), 11(10), 5010-5016

Quality by design approach for development and validation of stability indicating RP-​HPLC method for fosaprepitant dimeglumine
By Shaikh, Jalil K.; Farooqui, Mazahar; Syed, Ummul Khair Asema
From Asian Journal of Chemistry (2020), 32(9), 2158-2164