Chemical Name: 6α,9-difluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione, cyclic 16,17-acetal with acetone,21-acetate
Synonym: Flucetonide ; Flucinar ; Fluocinolide ; Fluocinolide acetate ; Fluocinolone acetonide acetate ; Topsym ; Topsyn
Smiles: O=C([C@]([C@@]1([H])C[C@@]2([H])[C@@](C[C@H](F)C3=CC4=O)([H])[C@@](F)([C@]3(C=C4)C)[C@@H](O)C5)(OC(C)(C)O1)[C@]25C)COC(C)=O
Inchi: InChI=1S/C21H26O2/c1-4-21(23)10-8-18-16-6-5-14-12-19(22)13(2)11-17(14)15(16)7-9-20(18,21)3/h1,11-12,15-16,18,22-23H,5-10H2,2-3H3/t15-,16+,18-,20-,21-/m0/s1
Generic Development of Topical Dermatologic Products: Formulation Development, Process Development, and Testing of Topical Dermatologic Products
Rong-Kun Chang,1 Andre Raw,1,2 Robert Lionberger,1 and Lawrence Yu1
AAPS J. 2013 Jan; 15(1): 41–52.
A Validated Stability-Indicating LC Method for Fluocinonide in the Presence of Degradation Products, Its Process-Related Impurities and Identification of Degradation Products
Prabha Srinivasu1,2, Devarakonda V. SubbaRao1, Raju V. K. Vegesna1, K. Sudhakar Babu
American Journal of Analytical Chemistry, 2010, 1, 113-126
Review article impurity profiling of drugs towards safety and efficacy: theory and practice
kiran r. dhangar, rakesh b. jagtap, sanjay j. surana and atul a. shirkhedkar
J. Chil. Chem. Soc., 62, Nº 2 (2017)
The determination of fluocinolone acetonide in formulated products
F. BAILEY, A. HOLBROOK AND R. J. MILLER
J. Pharm. Phavmac., 1966, 18, Suppl., 12s-16s