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Brexpiprazole Hydrochloride

SZ CAT No SZ-B011003
CAS No 1420987-74-1
Mol.F. C25H27N3O2S : HCl
Mol.Wt. 433.6 : 36.5
Inv. Status Custom Synthesis
Rel. CAS No 913611-97-9 (free base) ; 1427049-36-2 (HBr salt) ; 913612-39-2 (Sulfate salt)


Chemical Name: 7-[4-(4-Benzo[b]thien-4-yl-1-piperazinyl)butoxy]-2(1H)-quinolinone Hydrochloride; 7-[4-(4-(Benzo[b]thien-4-yl)-piperazin-1-yl)butoxy]-1H-quinolin-2-one Hydrochloride

Industry-Oriented Route Evaluation and Process Optimization for the Preparation of Brexpiprazole
Weiming Chen, Jin Suo, Yongjian Liu, Yuanchao Xie, Mingjun Wu, Fuqiang Zhu, Yifeng Nian, Haji Akber Aisa, and Jingshan Shen
Org. Process Res. Dev. 2019, 23, 5, 852–857
 
Development and Validation of Stability Indicating Assay Method and Characterization of Degradation Product for Brexpiprazole Bulk by RP-HPLC
Nehal P Bhatt1*, Ashok B Patel1 , Mohana Rao Sanaka2 , Amit J Vyas1 , Nilesh K Patel1 and Ajay I Patel
Journal of Chemical and Pharmaceutical Research, 2018, 10(1):55-66
 
Qualification of impurities based on metabolite data.
LarsWeidolf,ThomasAndersson,JoelP.Bercu,AndreasBrink,SusanneGlowienke,JamesHarvey,Martin A.Hayes,PascaleJacques,ChuangLu,NenadManevski,WolfgangMuster,RaphaelNudelman,RonOgilvie,JennyOttosson,AndrewTeasdale,BruceTrela
Regulatory Toxicology and Pharmacology Volume 110, February 2020, 104524