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Atenolol 2-Hydroxy Impurity

SZ CAT No SZ-A035012
CAS No 68373-10-4
Mol.F. C14H22N2O4
Mol.Wt. 282.3
Inv. Status Custom Synthesis


Chemical Name: 2-Hydroxy-2-(4-(2-hydroxy-3-(isopropylamino)propoxy)phenyl)acetamide

Synonym: Atenolol 2-Hydroxy Impurity ;Atenolol 2-Hydroxy Metabolite ;

Smiles: O=C(N)C(O)C1=CC=C(OCC(O)CNC(C)C)C=C1

Inchi: InChI=1S/C14H21NO4/c1-10(2)15-8-12(16)9-19-13-5-3-11(4-6-13)7-14(17)18/h3-6,10,12,15-16H,7-9H2,1-2H3,(H,17,18)/t12-/m0/s1

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Zen pawlak* and Brian j. clark
Journal of Pharmaceutical & Biomedical Analysis Vol. 10, No. 5, pp. 329-334,1992
 
Removal of Atenolol and Isoproturon in Aqueous Solutions by Adsorption in a Fixed-Bed Column
JoséLuis Sotelo, Gabriel Ovejero, Araceli Rodríguez, Silvia Á lvarez, and Juan García
Ind. Eng. Chem. Res. 2012, 51, 5045−5055
 
A simple, selective, and sensitive gas chromatography-mass spectrometry method for the analysis of five process-related impurities in atenolol bulk drug and capsule formulations
Ambavaram Vijaya Bhaskar Reddy  Zulkifli Yusop  Jafariah Jaafar  Azmi Bin Aris  Zaiton Abdul Majid
JSS Volume 40, Issue 15 Pages: 3016-3182 August 2017
 
A Sensitive and Selective GC–MS Method for Analysis of Process-Related Genotoxic Impurities in Atenolol
Yogeshwar Reddy Mamilla1,3,&, Kista Reddy Chetyala3 , Ramesh Venna2 , Raju Gajjela2 , Kishore Katragadda1 , Saravanan Govindasamy1 , Suryanarayana Mulukutla1 , Debashish Datta
Chromatographia 2010, 71, 733–736
 
Development and validation of liquid chromatographic method for atenolol and its related substance
Nandini R. Pai* and Swapnali Suhas Patil
Der Pharmacia Sinica, 2013, 4(2):76-84