Chemical Name: (2RS)-2,3-Bis[3-(1-cyano-1-methylethyl)-5-(1H-1,2,4-triazol-1-ylmethyl)phenyl]-2-methylpropanenitrile (as per EP) ; 2,3-Bis(3-(1-cyano-1-methylethyl)-5-(1H-1,2,4-triazol-1-ylmethyl)phenyl)-2-methylpropionitrile (as per USP)
Synonym: Anastrozole Dimer Impurity
Smiles: CC(CC1=CC(CN2N=CN=C2)=CC(C(C)(C)C#N)=C1)(C3=CC(CN4N=CN=C4)=CC(C(C)(C)C#N)=C3)C#N
Inchi: InChI=1/C16H17N5/c1-12(7-17)14-4-13(8-21-11-19-10-20-21)5-15(6-14)16(2,3)9-18/h4-6,10-12H,8H2,1-3H3
LC and LC–MS/MS study of forced decomposition behavior of anastrozole and establishment of validated stability-indicating analytical method for impurities estimation in low dose anastrozole tablets
Y. Ramachandra Reddy b,∗, Srinivasan R. Nandana,b,∗∗, D. Vijaya Bharathi c, B. Nagarajua, S. Saidu Reddy b, L.K. Ravindranathb, V. Suryanarayan Rao b
Journal of Pharmaceutical and Biomedical Analysis 50 (2009) 397–404
Preparation of anastrozole loaded PEG-PLA nanoparticles: evaluation of apoptotic response of breast cancer cell lines
Yusra A Alyafee,1,2 Manal Alaamery,1 Shahad Bawazeer,1 Mansour S Almutairi,1 Badr Alghamdi,1 Nawaf Alomran,1 Atia Sheereen,1 Maha Daghestani,2 and Salam Massadeh1,3
Int J Nanomedicine. 2018; 13: 199–208.
Isolation and characterization of process related impurities in anastrozole active pharmaceutical ingredient
S. G. Hiriyanna*; K. Basavaiah
J. Braz. Chem. Soc., Vol. 19, No. 3, 397-404, 2008.