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Abacavir EP Impurity E

SZ CAT No SZ-A049006
CAS No 208762-35-0
Mol.F. C14H20N6O
Mol.Wt. 288.4
Inv. Status Custom Synthesis


Chemical Name: [(1R,3S)-3-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopentyl]methanol (as per EP)

Synonym: Dihydro Abacavir

Smiles: [H][C@@]1(CC[C@](CO)([H])C1)N2C3=NC(N)=NC(NC4CC4)=C3N=C2

Inchi: InChI=1S/C14H18N6O/c15-14-18-12(17-9-2-3-9)11-13(19-14)20(7-16-11)10-4-1-8(5-10)6-21/h1,4,7-10,21H,2-3,5-6H2,(H3,15,17,18,19)/t8-,10-/m0/s1

Stability indicating RP-​HPLC method development and validation for determination of abacavir sulphate in tablet dosage form
By Ithape, Aniket B.; Deshpande, Padmanabh B.; Shelke, Priyanka
From International Journal of Pharmacy and Pharmaceutical Research (2020), 17(4), 670-680
 
A new stability indicating method was developed and validated for the simultaneous estimation of Lamivudine and Abacavir in tablet dosage form by RP-​HPLC
By Rajamahanti, Santoshi G.; Annapurna, N.; Santosh, T.; Durga, B.; Raziya, S. K.
From Research Journal of Pharmaceutical, Biological and Chemical Sciences (2017), 8(3), 407-421
 
A validated stability-​indicating RP-​HPLC method for abacavir sulfate in the presence of degradation products, its process-​related impurities and identification of oxidative degradant by LC-​MS​/MS
By Ragham, Pramod Kumar; Chandrasekhar, Kothapalli B.; Reddy, J. Rudraprasad; Kasturi, Krishna Mohan
From Indo American Journal of Pharmaceutical Research (2015), 5(1), 463-473