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Tacrolimus Impurity I

SZ目录编号 SZ-T005016
CAS 号 135821-69-1
分子式 C44H71NO12
分子量 806
投资状态 Custom Synthesis


化学名称: (E)-1, 14-Dihydroxy-12-[(E)-2-(4-hydroxy-3-methoxycyclohexy)-1-1methylethenyl]-23, 25-dimethoxy-13, 19, 21, 27-tetramethyl-11, 28-dioxa-17-propyl-4-azatricyclo[22.3.1.04.9]octacos-18-ene-2, 3, 10, 16-tetrone

Solid state compatibility study and characterization of a novel degradation product of tacrolimus in formulation
Tanja Rozman Peterka∗, Rok Grahek, Jure Hren, Andrej Bastarda, Jure Bergles, Urosˇ Urleb
Journal of Pharmaceutical and Biomedical Analysis 110 (2015) 67–75
 
Forced degradation of tacrolimus and the development of a UHPLC method for impurities determination
Tanja Rozman Peterka 1 , Tina Trdan Lušin 1 , Jure Bergles 1 , Zoran Ham 1 , Rok Grahek 1 , and Uroš Urleb 1
Acta Pharm. 69 (2019) 363–380
 
Development and Validation of method for the determination of related substances of Tacrolimus in Tacrolimus Capsules and Degradation Studies
Qingping Shi*1,2, Jianchun Li2 , Feng Ding
International Journal of ChemTech Research Vol.4, No.4, pp 1543-1552,
 
Reutilization of Tacrolimus Extracted from Expired Prograf Capsules: Physical, Chemical, and Pharmacological Assessment
Ziyad Binkhathlan, Mohamed M. Badran, Abdullah Alomrani, Ibrahim A. Aljuffali, Mohammed Alghonaim, Saleh Al-Muhsen, Rabih Halwani & Aws Alshamsan
AAPS PharmSciTech volume 17, pages978–987(2016)