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Tacrolimus Hydrate

SZ目录编号 SZ-T005001
CAS 号 109581-93-3
分子式 C44H69NO12 : H2O
分子量 804.0 : 18.0
投资状态 In Stock
Rel. CAS No 104987-11-3 (anhydrous)


化学名称: (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-[(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(prop-2-en-1-yl)-3,4,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-octadecahydro-7H-15,19-epoxypyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(23H)-tetrone monohydrate (as per EP); (−)-(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-8-Allyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylvinyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone monohydrate (as per USP)

Solid state compatibility study and characterization of a novel degradation product of tacrolimus in formulation
Tanja Rozman Peterka∗, Rok Grahek, Jure Hren, Andrej Bastarda, Jure Bergles, Urosˇ Urleb
Journal of Pharmaceutical and Biomedical Analysis 110 (2015) 67–75
 
Forced degradation of tacrolimus and the development of a UHPLC method for impurities determination
Tanja Rozman Peterka 1 , Tina Trdan Lušin 1 , Jure Bergles 1 , Zoran Ham 1 , Rok Grahek 1 , and Uroš Urleb 1
Acta Pharm. 69 (2019) 363–380
 
Development and Validation of method for the determination of related substances of Tacrolimus in Tacrolimus Capsules and Degradation Studies
Qingping Shi*1,2, Jianchun Li2 , Feng Ding
International Journal of ChemTech Research Vol.4, No.4, pp 1543-1552,
 
Reutilization of Tacrolimus Extracted from Expired Prograf Capsules: Physical, Chemical, and Pharmacological Assessment
Ziyad Binkhathlan, Mohamed M. Badran, Abdullah Alomrani, Ibrahim A. Aljuffali, Mohammed Alghonaim, Saleh Al-Muhsen, Rabih Halwani & Aws Alshamsan
AAPS PharmSciTech volume 17, pages978–987(2016)