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Tacrolimus 21-Carboxylic acid Impurity

SZ目录编号 SZ-T005010
CAS 号 NA
分子式 C44H71NO13
分子量 822.1
投资状态 Under Synthesis


化学名称: 2-((2R,3R,5S)-6-((1S,3S,5Z,7R,10S,11R,12S,13E)-7-allyl-10-hydroxy-14-((1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl)-1-methoxy-3,5,11,13-tetramethyl-8-oxo-12-(((S)-piperidine-2-carbonyl)oxy)tetradeca-5,13-dien-1-yl)-2-hydroxy-5-methoxy-3-methyltetrahydro-2H-pyran-2-yl)-2-oxoacetic acid

Solid state compatibility study and characterization of a novel degradation product of tacrolimus in formulation
Tanja Rozman Peterka∗, Rok Grahek, Jure Hren, Andrej Bastarda, Jure Bergles, Urosˇ Urleb
Journal of Pharmaceutical and Biomedical Analysis 110 (2015) 67–75
 
Forced degradation of tacrolimus and the development of a UHPLC method for impurities determination
Tanja Rozman Peterka 1 , Tina Trdan Lušin 1 , Jure Bergles 1 , Zoran Ham 1 , Rok Grahek 1 , and Uroš Urleb 1
Acta Pharm. 69 (2019) 363–380
 
Development and Validation of method for the determination of related substances of Tacrolimus in Tacrolimus Capsules and Degradation Studies
Qingping Shi*1,2, Jianchun Li2 , Feng Ding
International Journal of ChemTech Research Vol.4, No.4, pp 1543-1552,
 
Reutilization of Tacrolimus Extracted from Expired Prograf Capsules: Physical, Chemical, and Pharmacological Assessment
Ziyad Binkhathlan, Mohamed M. Badran, Abdullah Alomrani, Ibrahim A. Aljuffali, Mohammed Alghonaim, Saleh Al-Muhsen, Rabih Halwani & Aws Alshamsan
AAPS PharmSciTech volume 17, pages978–987(2016)