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Sacubitril Impurity 37

SZ目录编号 SZ-S020048
CAS 号 1573000-36-8
分子式 C19H18ClNO2
分子量 327.8
投资状态 Custom Synthesis

化学名称: (R)-1-(1-([1,1'-Biphenyl]-4-yl)-3-chloropropan-2-yl)pyrrolidine-2,5-dione

微笑: ClC[C@H](N(C1=O)C(CC1)=O)CC2=CC=C(C3=CC=CC=C3)C=C2

印地语: InChI=1/C29H28N4O7/c1-3-38-29-30-23-11-7-10-22(28(37)39-17-25(35)18(2)34)27(23)32(29)15-19-12-13-21(20-8-5-4-6-9-20)24(14-19)33-16-26(36)40-31-33/h4-14,25,31,35H,3,15-17H2,1-2H3

A liquid chromatographic method for separation of sacubitril–valsartan and their stereoisomeric impurities
Lu Zhou,  Liang Zou,  Lili Sun,  Hui Zhang,  Wenkai Hui and  Qiaogen Zou
Anal. Methods, 2018,10, 1046-1053
Quantification of potential genotoxic impurity in sacubitril/valsartan drug substance at ppm level by LC-MS/MS
Ravi Uppala, M.Arthanareeswari, S.Devikala,T.Pushpamalini, J. ArockiaSelvi
Materials Today: Proceedings Volume 14, Part 2, 2019, Pages 640-645
Experimental Design Approach in HPLC Method Development: Application for the Simultaneous Determination of Sacubitril and Valsartan in Presence of Their Impurities and Investigation of Degradation Kinetics
Bahia A. Moussa, Hanaa M. A. Hashem, Marianne A. Mahrouse & Sally T. Mahmoud
Chromatographia volume 81, pages139–156(2018)
Development and validation of a stability indicating UHPLC method for Sacubitril/Valsartan complex in the presence of impurities and degradation products
Pintu Prajapati, Dhara Bhayani, Priti Mehta.
J App Pharm Sci. 2020; 10(2): 97-107