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Nicardipine N-Desbenzyl Impurity

SZ目录编号 SZ-N004018
CAS 号 58368-87-9
分子式 C19H23N3O6
分子量 389.4
投资状态 Under Synthesis


化学名称: 3-Methyl 5-(2-(methylamino)ethyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

异名: Nicardipine Methylamino Derivative

微笑: O=C(C(C(C1=CC([N](=O)=O)=CC=C1)C(C(OC)=O)=C(C)N2)=C2C)OCCNC

印地语: InChI=1S/C14H22N2O5S/c1-5-16(6-2,21-22(18,19)20)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H-,15,17,18,19,20)/p+1

Stability-indicating HPLC method for the determination of nicardipine in capsules and spiked human plasma. Identification of degradation products using HPLC/MS
Sheikha M.Al-Ghannam,Abeer M.Al-Olayan
Arabian Journal of Chemistry Volume 12, Issue 8, December 2019, Pages 1983-1993
 
Employing ionization behaviors to resolve a trace-level impurity: determination of 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5- pyridinedicarboxylic acid di-2-[methyl-(phenylmethyl)amino]ethyl ester in nicardipine drug substance
M B Maurin 1, R D Vickery, P Ma, J Manalo, M A Hussain
Pharm Res. 1992 Nov;9(11):1518-20.
 
Chromatographic purity and assay of nicardipine by HPLC
C. V. Fernández  D. F. Mira  G. I. Luque
Journal of High Resolution Chromatography Volume13, Issue12 December 1990 Pages 846-849
 
Identification and characterization of a novel potential degradant and development and validation of stability-indicating rp-lc method for nicardipine impurities in injectable dosage form
Bhupendrasinh K. Vaghela  &Surendra Singh Rao
Journal of Liquid Chromatography & Related Technologies  Volume 36, 2013 - Issue 15 Pages 2166-2181