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N-Nitroso Sacubitril Valsartan

SZ目录编号 SZ-S020056
分子式 C24H29NO5 : C24H28N6O4
分子量 411.5 : 464.5
投资状态 Custom Synthesis

化学名称: N-((2'-(1-Nitroso-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-N-pentanoyl-L-valine compound with 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid (1:1)

微笑: O=C(CCC(O)=O)N[C@@H](C[C@@H](C)C(OCC)=O)CC(C=C1)=CC=C1C2=CC=CC=C2.OC([C@@H](N(CC3=CC=C(C4=C(C5=NN=NN5N=O)C=CC=C4)C=C3)C(CCCC)=O)C(C)C)=O

印地语: InChI=1S/C21H25FN4O7S/c1-12(2)19-17(9-8-15(27)10-16(28)11-18(29)30)20(13-4-6-14(22)7-5-13)24-21(23-19)26(25-31)34(3,32)33/h4-9,12,15-16,27-28H,10-11H2,1-3H3,(H,29,30)/b9-8+/t15-,16-/m1/s1

A liquid chromatographic method for separation of sacubitril–valsartan and their stereoisomeric impurities
Lu Zhou,  Liang Zou,  Lili Sun,  Hui Zhang,  Wenkai Hui and  Qiaogen Zou
Anal. Methods, 2018,10, 1046-1053
Quantification of potential genotoxic impurity in sacubitril/valsartan drug substance at ppm level by LC-MS/MS
Ravi Uppala, M.Arthanareeswari, S.Devikala,T.Pushpamalini, J. ArockiaSelvi
Materials Today: Proceedings Volume 14, Part 2, 2019, Pages 640-645
Experimental Design Approach in HPLC Method Development: Application for the Simultaneous Determination of Sacubitril and Valsartan in Presence of Their Impurities and Investigation of Degradation Kinetics
Bahia A. Moussa, Hanaa M. A. Hashem, Marianne A. Mahrouse & Sally T. Mahmoud
Chromatographia volume 81, pages139–156(2018)
Development and validation of a stability indicating UHPLC method for Sacubitril/Valsartan complex in the presence of impurities and degradation products
Pintu Prajapati, Dhara Bhayani, Priti Mehta.
J App Pharm Sci. 2020; 10(2): 97-107