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Abacavir EP Impurity B

SZ目录编号 SZ-A049003
CAS 号 1443421-69-9
分子式 C18H21ClN10O
分子量 428.9
投资状态 Custom Synthesis


化学名称: 6-(Cyclopropylamino)-9-[(1R,4S)-4-[[(2,5-diamino-6-chloropyrimidin-4-yl)oxy]methyl]cyclopent-2-enyl]-9H-purine-2-amine (as per EP); N6-Cyclopropyl-9-{(1R,4S)-4-[(2,5-diamino-6-chloropyrimidin-4-yloxy)methyl]cyclopent-2-enyl}-9H-purine-2,6-diamine (as per USP)

异名: O-Pyrimidine derivative abacavir (USP) ; Abacavir Related Compound D

微笑: NC1=NC(NC2CC2)=C(N=CN3[C@@H]4C[C@H](COC5=NC(N)=NC(Cl)=C5N)C=C4)C3=N1

印地语: InChI=1S/C50H72N16O22S2/c1-15-28(63-41(66-39(15)53)20(7-26(52)70)58-8-19(51)40(54)76)44(79)65-30(36(21-9-56-14-59-21)86-49-38(34(74)32(72)24(10-67)85-49)87-48-35(75)37(88-50(55)83)33(73)25(11-68)84-48)45(80)60-17(3)31(71)16(2)42(77)64-29(18(4)69)43(78)57-6-5-27-61-22(12-89-27)46-62-23(13-90-46)47(81)82/h9,12-14,16-20,24-25,29-38,48-49,58,67-69,71-75H,5-8,10-11,51H2,1-4H3,(H2,52,70)(H2,54,76)(H2,55,83)(H,56,59)(H,57,78)(H,60,80)(H,64,77)(H,65,79)(H,81,82)(H2,53,63,66)/t16-,17+,18+,19-,20-,24-,25+,29-,30-,31-,32+,33+,34-,35-,36?,37-,38-,48+,49-/m0/s1

Stability indicating RP-​HPLC method development and validation for determination of abacavir sulphate in tablet dosage form
By Ithape, Aniket B.; Deshpande, Padmanabh B.; Shelke, Priyanka
From International Journal of Pharmacy and Pharmaceutical Research (2020), 17(4), 670-680
 
A new stability indicating method was developed and validated for the simultaneous estimation of Lamivudine and Abacavir in tablet dosage form by RP-​HPLC
By Rajamahanti, Santoshi G.; Annapurna, N.; Santosh, T.; Durga, B.; Raziya, S. K.
From Research Journal of Pharmaceutical, Biological and Chemical Sciences (2017), 8(3), 407-421
 
A validated stability-​indicating RP-​HPLC method for abacavir sulfate in the presence of degradation products, its process-​related impurities and identification of oxidative degradant by LC-​MS​/MS
By Ragham, Pramod Kumar; Chandrasekhar, Kothapalli B.; Reddy, J. Rudraprasad; Kasturi, Krishna Mohan
From Indo American Journal of Pharmaceutical Research (2015), 5(1), 463-473