Chemical Name: 4,4′-[Carbonylbis(azanediyl-4,1-phenyleneoxy)]bis(N-methylpyridine-2-carboxamide) (as per EP) N,N’-Bis{4-[2-(N-methylcarbamoyl)-4-pyridyloxy]phenyl}urea (as per USP)
Synonym: Sorafenib USP Impurity E
Smiles: O=C(NC)C1=CC(OC2=CC=C(NC(NC3=CC=C(OC4=CC=NC(C(NC)=O)=C4)C=C3)=O)C=C2)=CC=N1
Inchi: InChI=1S/C16H17N3O4/c1-3-22-16(21)19-11-4-6-12(7-5-11)23-13-8-9-18-14(10-13)15(20)17-2/h4-10H,3H2,1-2H3,(H,17,20)(H,19,21)
Fragmentation pathways and differentiation of positional isomers of sorafenib and structural analogues by ESI-IT-MSn and ESI-Q-TOF-MS/MS coupled with DFT calculations
By Yu, Dandan; Liang, Xianrui
From Journal of Mass Spectrometry (2018), 53(7), 579-589.
Box-Behnken design based statistical modelling for optimization of U PLC-MS/MS method for analysis of sorafenib in bulk and tablets
By Wanii, Tanveer A.; Alanazi, Amer M.; Zargar, Seema; Ahmad, Ajaz; Drawish, Ibrahim A.
From Journal of Computational and Theoretical Nanoscience (2015), 12(10), 3598-3604
Determination of sorafenib in human plasma by HPLC
By Liu, Weifeng; Cao, Pengjian; Zhang, Chunfang; Xia, Dongxia; Che, Shujuan; Lou, Dan; Qiu, Xiangjun
From Zhongguo Xiandai Yingyong Yaoxue (2015), 32(2), 182-185