Chemical Name: 4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic Acid
Synonym: Pemetrexed acid
Smiles: O=C(O)C1=CC=C(CCC2=CNC(N=C(N)N3)=C2C3=O)C=C1
Inchi: InChI=1S/C18H20FN3O4/c1-18(2)22-9-11(17(24)25)15(23)10-8-12(19)14(16(26-18)13(10)22)21-6-4-20(3)5-7-21/h8-9H,4-7H2,1-3H3,(H,24,25)
A stability-indicating LC-MS/MS method optimization for Pemetrexed through design of experiments: Identification and characterization of major oxidative degradation product
By Narenderan, S. T.; Ramesh, J.; Babu, B.; Meyyanathan, S. N.
From Journal of Pharmaceutical and Biomedical Analysis (2020), 183, 113150
A new validated stability-indicating gradient RP-HPLC method for the determination of pemetrexed disodium and its process related substances
By Hemchand, S.; Babu, R. Ravi Chandra; Annapurna, Mukthinuthalapati Mathrusri
From Journal of Drug Delivery and Therapeutics (2019), 9(3Suppl.), 588-610
Content determination of related impurity-L-isomer in Pemetrexed Disodium for injection by HPLC
By Li, Jinhua; Yang, Mei
From Heilongjiang Yiyao (2014), 27(3), 498-500