Chemical Name: (2RS)-7-chloro-2-methyl-4-oxo-3-phenyl1,2,3,4-tetrahydroquinazoline-6-sulfonamide (as per EP)
Synonym: Metolazone USP Related Compound A ; Desmethyl metolazone
Smiles: O=C1C2=CC([S](N)(=O)=O)=C(Cl)C=C2NC(C)N1C3=CC=CC=C3
Inchi: InChI=1/C16H16ClN3O3S/c1-9-3-5-11(6-4-9)20-10(2)19-14-8-13(17)15(24(18,22)23)7-12(14)16(20)21/h3-8,10,19H,1-2H3,(H2,18,22,23)
Determination of a Metolazone metabolite in human urine by high‐performance liquid chromatography/diode‐array detection, high‐performance liquid chromatography/electrospray ionization mass spectrometry and gas chromatography/mass spectrometry
Yunje Kim Sungil Kim Myungsoo Kim Won Lee
Rapid Commun. Mass Spectrom. 2004; 18: 917–922
Analytical method development and validation of simultaneous estimation of Metolazone and Spironolactone in bulk and pharmaceutical dosage form by RP-HPLC
G.Pallavi , A.Ravi Kumar
Indian Journal of Research in Pharmacy and Biotechnology 2(6) ; 2320 – 3471