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Sorafenib Sulfate

SZ CAT No SZ-S012020
CAS No 1280217-32-4
Mol.F. C21H16ClF3N4O3 : H2SO4
Mol.Wt. 464.8 : 98.1
Inv. Status Custom Synthesis
Rel. CAS No 475207-59-1 (Tosylate salt) ; 1199618-57-9 (HCl salt) ; 284461-73-0 (free base) ; 1280217-32-4 (Sulfate salt)


Chemical Name: 4-[4-[[[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl]amino]phenoxy]-N-methylpyridine-2-carboxamide Sulfate (as per EP); 4-(4-{3-[4-Chloro-3-(trifluoromethyl)phenyl]ureido}phenoxy)-N2-methylpyridine-2-carboxamide mono (Sulfate) (as per USP)

Smiles: CNC(C1=CC(OC2=CC=C(NC(NC3=CC=C(Cl)C(C(F)(F)F)=C3)=O)C=C2)=CC=N1)=O.O=[S](O)(O)=O

Inchi: InChI=1S/C21H16ClF3N4O3.BrH/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25;/h2-11H,1H3,(H,26,30)(H2,28,29,31);1H

Fragmentation pathways and differentiation of positional isomers of sorafenib and structural analogues by ESI-IT-MSn and ESI-Q-TOF-MS/MS coupled with DFT calculations
By Yu, Dandan; Liang, Xianrui
From Journal of Mass Spectrometry (2018), 53(7), 579-589.
 
Box-Behnken design based statistical modelling for optimization of U PLC-MS/MS method for analysis of sorafenib in bulk and tablets
By Wanii, Tanveer A.; Alanazi, Amer M.; Zargar, Seema; Ahmad, Ajaz; Drawish, Ibrahim A.
From Journal of Computational and Theoretical Nanoscience (2015), 12(10), 3598-3604

Determination of sorafenib in human plasma by HPLC
By Liu, Weifeng; Cao, Pengjian; Zhang, Chunfang; Xia, Dongxia; Che, Shujuan; Lou, Dan; Qiu, Xiangjun
From Zhongguo Xiandai Yingyong Yaoxue (2015), 32(2), 182-185