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Sorafenib EP Impurity F Tosylate

SZ CAT No SZ-S012010
CAS No 1285534-33-9
Mol.F. C21H17F3N4O3 : C7H8O3S
Mol.Wt. 430.4 : 172.2
Inv. Status Custom Synthesis
Rel. CAS No 1285534-09-9 (HCl salt) ; 1285533-84-7 (free base)

Chemical Name: N-Methyl-4-[4-[[[3-(trifluoromethyl)phenyl]carbamoyl]amino]phenoxy]pyridine-2-carboxamide Tosylate (as per EP) N-Methyl-4-{4-[3-(3-trifluoromethylphenyl)ureido]phenoxy}picolinamide Tosylate (as per USP)

Smiles: O=C(NC)C1=CC(OC2=CC=C(NC(NC3=CC(C(F)(F)F)=CC=C3)=O)C=C2)=CC=N1.O=[S](O)(C4=CC=C(C)C=C4)=O

Inchi: InChI=1S/C21H17F3N4O3.ClH/c1-25-19(29)18-12-17(9-10-26-18)31-16-7-5-14(6-8-16)27-20(30)28-15-4-2-3-13(11-15)21(22,23)24;/h2-12H,1H3,(H,25,29)(H2,27,28,30);1H

Fragmentation pathways and differentiation of positional isomers of sorafenib and structural analogues by ESI-IT-MSn and ESI-Q-TOF-MS/MS coupled with DFT calculations
By Yu, Dandan; Liang, Xianrui
From Journal of Mass Spectrometry (2018), 53(7), 579-589.
Box-Behnken design based statistical modelling for optimization of U PLC-MS/MS method for analysis of sorafenib in bulk and tablets
By Wanii, Tanveer A.; Alanazi, Amer M.; Zargar, Seema; Ahmad, Ajaz; Drawish, Ibrahim A.
From Journal of Computational and Theoretical Nanoscience (2015), 12(10), 3598-3604

Determination of sorafenib in human plasma by HPLC
By Liu, Weifeng; Cao, Pengjian; Zhang, Chunfang; Xia, Dongxia; Che, Shujuan; Lou, Dan; Qiu, Xiangjun
From Zhongguo Xiandai Yingyong Yaoxue (2015), 32(2), 182-185