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Sorafenib EP Impurity F Hydrochloride

SZ CAT No SZ-S012007
CAS No 1285534-09-9
Mol.F. C21H17F3N4O3 : HCl
Mol.Wt. 430.4 : 36.5
Inv. Status Custom Synthesis
Rel. CAS No 1285533-84-7 (free base) ; 1285534-33-9 (Tosylate)

Chemical Name: N-Methyl-4-[4-[[[3-(trifluoromethyl)phenyl]carbamoyl]amino]phenoxy]pyridine-2-carboxamide Hydrochloride (as per EP) N-Methyl-4-{4-[3-(3-trifluoromethylphenyl)ureido]phenoxy}picolinamide Hydrochloride (as per USP)

Smiles: O=C(NC)C1=CC(OC2=CC=C(NC(NC3=CC(C(F)(F)F)=CC=C3)=O)C=C2)=CC=N1.Cl

Inchi: InChI=1S/C16H13N3O3/c17-15(21)18-16(22)19-12-7-3-1-5-10(12)9-14(20)11-6-2-4-8-13(11)19/h1-8H,9H2,(H3,17,18,21,22)

Fragmentation pathways and differentiation of positional isomers of sorafenib and structural analogues by ESI-IT-MSn and ESI-Q-TOF-MS/MS coupled with DFT calculations
By Yu, Dandan; Liang, Xianrui
From Journal of Mass Spectrometry (2018), 53(7), 579-589.
Box-Behnken design based statistical modelling for optimization of U PLC-MS/MS method for analysis of sorafenib in bulk and tablets
By Wanii, Tanveer A.; Alanazi, Amer M.; Zargar, Seema; Ahmad, Ajaz; Drawish, Ibrahim A.
From Journal of Computational and Theoretical Nanoscience (2015), 12(10), 3598-3604

Determination of sorafenib in human plasma by HPLC
By Liu, Weifeng; Cao, Pengjian; Zhang, Chunfang; Xia, Dongxia; Che, Shujuan; Lou, Dan; Qiu, Xiangjun
From Zhongguo Xiandai Yingyong Yaoxue (2015), 32(2), 182-185