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Sorafenib EP Impurity C Hydrochloride

SZ CAT No SZ-S012011
CAS No 53313-44-3
Mol.F. C7H5ClF3N : HCl
Mol.Wt. 195.6 : 36.5
Inv. Status Custom Synthesis
Rel. CAS No 320-51-4 (free base)

Chemical Name: 4-Chloro-3-(trifluoromethyl)aniline Hydrochloride (as per EP & USP)

Smiles: FC(F)(C(C=C(N)C=C1)=C1Cl)F.Cl

Inchi: InChI=1S/C21H17F3N4O3.C7H8O3S/c1-25-19(29)18-12-17(9-10-26-18)31-16-7-5-14(6-8-16)27-20(30)28-15-4-2-3-13(11-15)21(22,23)24;1-6-2-4-7(5-3-6)11(8,9)10/h2-12H,1H3,(H,25,29)(H2,27,28,30);2-5H,1H3,(H,8,9,10)

Fragmentation pathways and differentiation of positional isomers of sorafenib and structural analogues by ESI-IT-MSn and ESI-Q-TOF-MS/MS coupled with DFT calculations
By Yu, Dandan; Liang, Xianrui
From Journal of Mass Spectrometry (2018), 53(7), 579-589.
Box-Behnken design based statistical modelling for optimization of U PLC-MS/MS method for analysis of sorafenib in bulk and tablets
By Wanii, Tanveer A.; Alanazi, Amer M.; Zargar, Seema; Ahmad, Ajaz; Drawish, Ibrahim A.
From Journal of Computational and Theoretical Nanoscience (2015), 12(10), 3598-3604

Determination of sorafenib in human plasma by HPLC
By Liu, Weifeng; Cao, Pengjian; Zhang, Chunfang; Xia, Dongxia; Che, Shujuan; Lou, Dan; Qiu, Xiangjun
From Zhongguo Xiandai Yingyong Yaoxue (2015), 32(2), 182-185