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Sorafenib EP Impurity A Hydrochloride

SZ CAT No SZ-S012012
CAS No 911132-05-3
Mol.F. C13H13N3O2 : HCl
Mol.Wt. 243.3 : 36.5
Inv. Status Custom Synthesis
Rel. CAS No 284462-37-9 (free base)

Chemical Name: 4-(4-Aminophenoxy)-N-methylpyridine-2-carboxamide Hydrochloride (as per EP); 4-(4-Aminophenoxy)-N-methylpicolinamide Hydrochloride (as per USP)

Smiles: O=C(NC)C1=CC(OC2=CC=C(N)C=C2)=CC=N1.Cl

Inchi: InChI=1S/C7H5ClF3N.ClH/c8-6-2-1-4(12)3-5(6)7(9,10)11;/h1-3H,12H2;1H

Fragmentation pathways and differentiation of positional isomers of sorafenib and structural analogues by ESI-IT-MSn and ESI-Q-TOF-MS/MS coupled with DFT calculations
By Yu, Dandan; Liang, Xianrui
From Journal of Mass Spectrometry (2018), 53(7), 579-589.
Box-Behnken design based statistical modelling for optimization of U PLC-MS/MS method for analysis of sorafenib in bulk and tablets
By Wanii, Tanveer A.; Alanazi, Amer M.; Zargar, Seema; Ahmad, Ajaz; Drawish, Ibrahim A.
From Journal of Computational and Theoretical Nanoscience (2015), 12(10), 3598-3604

Determination of sorafenib in human plasma by HPLC
By Liu, Weifeng; Cao, Pengjian; Zhang, Chunfang; Xia, Dongxia; Che, Shujuan; Lou, Dan; Qiu, Xiangjun
From Zhongguo Xiandai Yingyong Yaoxue (2015), 32(2), 182-185