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Sacubitril Impurity 29

SZ CAT No SZ-S020035
CAS No 1038925-22-2
Mol.F. C18H19NO
Mol.Wt. 265.4
Inv. Status Custom Synthesis


Chemical Name: 5-([1,1'-Biphenyl]-4-ylmethyl)-3-methylpyrrolidin-2-one

Smiles: CC(C(N1)=O)CC1CC2=CC=C(C3=CC=CC=C3)C=C2

Inchi: InChI=1S/C32H40N6O9S2/c1-31(2)21(29(44)45)37-26(48-31)19(35-23(39)17(33)15-11-7-5-8-12-15)25(41)34-18(16-13-9-6-10-14-16)24(40)36-20(28(42)43)27-38-22(30(46)47)32(3,4)49-27/h5-14,17-22,26-27,37-38H,33H2,1-4H3,(H,34,41)(H,35,39)(H,36,40)(H,42,43)(H,44,45)(H,46,47)/t17-,18-,19-,20+,21+,22+,26?,27?/m1/s1

A liquid chromatographic method for separation of sacubitril–valsartan and their stereoisomeric impurities
Lu Zhou,  Liang Zou,  Lili Sun,  Hui Zhang,  Wenkai Hui and  Qiaogen Zou
Anal. Methods, 2018,10, 1046-1053
 
Quantification of potential genotoxic impurity in sacubitril/valsartan drug substance at ppm level by LC-MS/MS
Ravi Uppala, M.Arthanareeswari, S.Devikala,T.Pushpamalini, J. ArockiaSelvi
Materials Today: Proceedings Volume 14, Part 2, 2019, Pages 640-645
 
Experimental Design Approach in HPLC Method Development: Application for the Simultaneous Determination of Sacubitril and Valsartan in Presence of Their Impurities and Investigation of Degradation Kinetics
Bahia A. Moussa, Hanaa M. A. Hashem, Marianne A. Mahrouse & Sally T. Mahmoud
Chromatographia volume 81, pages139–156(2018)
 
Development and validation of a stability indicating UHPLC method for Sacubitril/Valsartan complex in the presence of impurities and degradation products
Pintu Prajapati, Dhara Bhayani, Priti Mehta.
J App Pharm Sci. 2020; 10(2): 97-107