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Sacubitril Impurity 19

SZ CAT No SZ-S020022
CAS No NA
Mol.F. C22H23NO4
Mol.Wt. 365.4
Inv. Status Custom Synthesis


Chemical Name: 4-((3R,5S)-5-([1,1'-Biphenyl]-4-ylmethyl)-3-methyl-2-oxocyclopentyl)-4-oxobutanoic acid

Smiles: O=C(C1C(CCC(O)=O)=O)[C@H](C)C[C@H]1CC(C=C2)=CC=C2C3=CC=CC=C3

A liquid chromatographic method for separation of sacubitril–valsartan and their stereoisomeric impurities
Lu Zhou,  Liang Zou,  Lili Sun,  Hui Zhang,  Wenkai Hui and  Qiaogen Zou
Anal. Methods, 2018,10, 1046-1053
 
Quantification of potential genotoxic impurity in sacubitril/valsartan drug substance at ppm level by LC-MS/MS
Ravi Uppala, M.Arthanareeswari, S.Devikala,T.Pushpamalini, J. ArockiaSelvi
Materials Today: Proceedings Volume 14, Part 2, 2019, Pages 640-645
 
Experimental Design Approach in HPLC Method Development: Application for the Simultaneous Determination of Sacubitril and Valsartan in Presence of Their Impurities and Investigation of Degradation Kinetics
Bahia A. Moussa, Hanaa M. A. Hashem, Marianne A. Mahrouse & Sally T. Mahmoud
Chromatographia volume 81, pages139–156(2018)
 
Development and validation of a stability indicating UHPLC method for Sacubitril/Valsartan complex in the presence of impurities and degradation products
Pintu Prajapati, Dhara Bhayani, Priti Mehta.
J App Pharm Sci. 2020; 10(2): 97-107