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Sacubitril Impurity 16

SZ CAT No SZ-S020019
CAS No 149709-49-9
Mol.F. C24H29NO5
Mol.Wt. 411.5
Inv. Status Custom Synthesis


Chemical Name: (2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-(4-ethoxy-4-oxobutanamido)-2-methylpentanoic acid

Smiles: OC([C@H](C)C[C@H](NC(CCC(OCC)=O)=O)CC(C=C1)=CC=C1C2=CC=CC=C2)=O

Inchi: InChI=1S/C27H35NO5/c1-5-32-27(31)20(4)17-24(28-25(29)15-16-26(30)33-19(2)3)18-21-11-13-23(14-12-21)22-9-7-6-8-10-22/h6-14,19-20,24H,5,15-18H2,1-4H3,(H,28,29)/t20-,24+/m1/s1

A liquid chromatographic method for separation of sacubitril–valsartan and their stereoisomeric impurities
Lu Zhou,  Liang Zou,  Lili Sun,  Hui Zhang,  Wenkai Hui and  Qiaogen Zou
Anal. Methods, 2018,10, 1046-1053
 
Quantification of potential genotoxic impurity in sacubitril/valsartan drug substance at ppm level by LC-MS/MS
Ravi Uppala, M.Arthanareeswari, S.Devikala,T.Pushpamalini, J. ArockiaSelvi
Materials Today: Proceedings Volume 14, Part 2, 2019, Pages 640-645
 
Experimental Design Approach in HPLC Method Development: Application for the Simultaneous Determination of Sacubitril and Valsartan in Presence of Their Impurities and Investigation of Degradation Kinetics
Bahia A. Moussa, Hanaa M. A. Hashem, Marianne A. Mahrouse & Sally T. Mahmoud
Chromatographia volume 81, pages139–156(2018)
 
Development and validation of a stability indicating UHPLC method for Sacubitril/Valsartan complex in the presence of impurities and degradation products
Pintu Prajapati, Dhara Bhayani, Priti Mehta.
J App Pharm Sci. 2020; 10(2): 97-107