Chemical Name: (2R,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride
Synonym: Aprepitant M2 Metabolite (1R,2R,3S)-Isomer
Smiles: C[C@H](C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)O[C@@H]2[C@H](C3=CC=C(F)C=C3)NCCO2.Cl
Inchi: InChI=1S/C12H20N2O/c1-10-3-9-4-11(2,6-10)8-12(5-9,7-10)13-14-15/h9H,3-8H2,1-2H3,(H,13,15)/t9-,10+,11-,12-
Application of analytical quality by design principles for the determination of alkyl p-toluenesulfonates impurities in Aprepitant by HPLC. Validation using total-error concept
Constantinos K. Zacharis, Elli Vastardi
Journal of Pharmaceutical and Biomedical Analysis Volume 150, 20 February 2018, Pages 152-161
Characterization and Quantitation of Aprepitant Drug Substance Polymorphs by Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy
Roy Helmy,* George X. Zhou, Yadan W. Chen, Louis Crocker, Tao Wang, Robert M. Wenslow, Jr., and Anant Vailaya*
Anal. Chem. 2003, 75, 605-611
Development and Optimization of Liquid Chromatography Analytical Methods by Using AQbD Principles: Overview and Recent Advances
Tim Tome,†,Nina Ž igart, Zdenko Č asar,, and AlešObreza
Org. Process Res. Dev. 2019, 23, 1784−1802